A significant number of new active pharmaceutical ingredients (APIs) are poorly water soluble and cannot be formulated and processed with traditional aqueous methods. Hot melt extrusion (HME) has become an effective solubilization tool in improving the dissolution rate of poorly water soluble drugs to enhance their bioavailability after oral administration1. These crystalline hydrophobic drugs can be dispersed in hydrophilic polymers using HME to manufacture amorphous solid dispersions.
Foster Delivery Science Brochures
Foster Delivery Science Technical Posters
- A Comparison of Saturated Solubility Enhancement via Spray Drying and Hot Melt Extrusion Processing
- Characterization of Solid Nifedipine Dispersions Produced by Melt Extrusion
- Effect of Processing Methods on Physical Stability of Amorphous Solid Dispersions Consisting of Naproxen and Povidone
- Resveratrol Incorporation into Melt Extrusions
- Study on the Blend of Kollidon SR and Ibuprofen Using Hot Melt Extrusion